CRIMESTAT is a program that interaces with ArcGIS and other desktop programs. The program itself conducts geostatistical analysis using crime and incident locations and times. The program is used widely across the nation for spatial analysis.
A good website to read up on it is MapCruzer! and CRAN's site. This tool can use geostatistics and spatial regression as well and read and write geodata. It also has special tools for disease analysis and ecological analysis.